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It's so well-established that researchers regularly use it as the go-to benchmark when testing new brightening ingredients

However, other studies have not always confirmed this association and clinical trials are lacking

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mTORC1 promotes the expression of lactate dehydrogenase A (LDHA) and Pyruvate kinase isozyme type M2 (PKM2) by activating HIF-1 and catalyzes the reductive carboxylation of glutamine to generate lipid precursors, thereby aggravating synovial inflammation (78, 79)

Some estimates show that every cell in your body takes 10,000 oxidative hits to its DNA daily